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Misbehaving lab mice 'are doing their own experiments'

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Friday May 17 2024

When scientists work with laboratory mice it is usually assumed that the humans are the ones doing the research.

A study suggests, however, that the rodents may often be surreptitiously carrying out their own experiments by making "mistakes" on purpose.

Scientists have long known that it is possible to train mice to perform certain tasks, such as pulling a lever when they hear a particular noise, by offering them rewards of food and drink.

These kinds of experiments are used to explore how memory works as well as to research potential treatments for conditions including Alzheimer's disease.

But the mice do not always perform as expected. Kishore Kuchibhotla, an assistant professor and neuroscientist at Johns Hopkins University who studies learning in humans and animals, said:

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